Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties
Complexes [RuCp(Adeninate–κN9)(mPTA)2](Cl0.5)(CF3SO3)2.5⋅H2O (1⋅H2O), [RuCp(Guaninate-κN7)(mPTA)2] (CF3SO3)2⋅H2O (2⋅H2O), [RuCp(Theophyllinate-κN7)(mPTA)2](CF3SO3)2⋅1.5H2O (3⋅1.5H2O) and [RuCp(Pur- κN)(mPTA)(PPh3)](CF3SO3) (4–6) (Pur = Adeninate, Guaninate, Teophyllinate; mPTA = N-methyl 1,3,5-t...
| Main Authors: | , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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2024
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10835/15051 |
| _version_ | 1789406703625699328 |
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| author | Hajji, Lazhar Saraiba Bello, Cristóbal Scalambra, Franco Segovia Torrente, Gaspar Francisco Romerosa Nievas, Antonio Manuel |
| author_facet | Hajji, Lazhar Saraiba Bello, Cristóbal Scalambra, Franco Segovia Torrente, Gaspar Francisco Romerosa Nievas, Antonio Manuel |
| author_sort | Hajji, Lazhar |
| collection | DSpace |
| description | Complexes [RuCp(Adeninate–κN9)(mPTA)2](Cl0.5)(CF3SO3)2.5⋅H2O (1⋅H2O), [RuCp(Guaninate-κN7)(mPTA)2]
(CF3SO3)2⋅H2O (2⋅H2O), [RuCp(Theophyllinate-κN7)(mPTA)2](CF3SO3)2⋅1.5H2O (3⋅1.5H2O) and [RuCp(Pur-
κN)(mPTA)(PPh3)](CF3SO3) (4–6) (Pur = Adeninate, Guaninate, Teophyllinate; mPTA = N-methyl 1,3,5-triaza-
7-phosphaadamantane) have been synthesized and characterized. Structure of complexes 1⋅H2O and
3⋅1.5H2O were determined by single-crystal X-ray diffraction. Solubility in water, Log P, electrochemical
properties and antiproliferative activities of the complexes (against cisplatin-sensitive T2 and cisplatin-resistant
SKOV3 cell lines) have been assessed and discussed. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-15051 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2024 |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-150512024-01-10T09:41:28Z Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties Hajji, Lazhar Saraiba Bello, Cristóbal Scalambra, Franco Segovia Torrente, Gaspar Francisco Romerosa Nievas, Antonio Manuel Antiproliferative activity Ruthenium Water-soluble complexes mPTA Natural purines Complexes [RuCp(Adeninate–κN9)(mPTA)2](Cl0.5)(CF3SO3)2.5⋅H2O (1⋅H2O), [RuCp(Guaninate-κN7)(mPTA)2] (CF3SO3)2⋅H2O (2⋅H2O), [RuCp(Theophyllinate-κN7)(mPTA)2](CF3SO3)2⋅1.5H2O (3⋅1.5H2O) and [RuCp(Pur- κN)(mPTA)(PPh3)](CF3SO3) (4–6) (Pur = Adeninate, Guaninate, Teophyllinate; mPTA = N-methyl 1,3,5-triaza- 7-phosphaadamantane) have been synthesized and characterized. Structure of complexes 1⋅H2O and 3⋅1.5H2O were determined by single-crystal X-ray diffraction. Solubility in water, Log P, electrochemical properties and antiproliferative activities of the complexes (against cisplatin-sensitive T2 and cisplatin-resistant SKOV3 cell lines) have been assessed and discussed. 2024-01-10T09:41:28Z 2024-01-10T09:41:28Z 2021 info:eu-repo/semantics/article http://hdl.handle.net/10835/15051 en Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess Journal of Inorganic Biochemistry 218 (2021) 111404, DOI: https://doi.org/10.1016/j.jinorgbio.2021.111404 |
| spellingShingle | Antiproliferative activity Ruthenium Water-soluble complexes mPTA Natural purines Hajji, Lazhar Saraiba Bello, Cristóbal Scalambra, Franco Segovia Torrente, Gaspar Francisco Romerosa Nievas, Antonio Manuel Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties |
| title | Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties |
| title_full | Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties |
| title_fullStr | Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties |
| title_full_unstemmed | Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties |
| title_short | Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties |
| title_sort | ru complexes containing cp, mpta and natural purine bases (mpta = methyl-n-1,3,5-triaza-7-phosphaadamantane): evaluation of their antiproliferative activity, solubility and redox properties |
| topic | Antiproliferative activity Ruthenium Water-soluble complexes mPTA Natural purines |
| url | http://hdl.handle.net/10835/15051 |
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