Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity.
[{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-N,N’-CuCl}2-μ-Cl-μ- OCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2- N,N’-NiCl}2-μ-Cl-μ-OH](CF3SO3)2 (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI50...
| Main Authors: | , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10835/15071 |
| _version_ | 1789406598479740928 |
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| author | Alguacil Alarcón, Andrés Scalambra, Franco Lorenzo Luis, Pablo Puerta, Adrián González-Bakker, Aday Mendoza Nozeman, Elisabet Zenaida Padrón, José M. Romerosa Nievas, Antonio Manuel |
| author_facet | Alguacil Alarcón, Andrés Scalambra, Franco Lorenzo Luis, Pablo Puerta, Adrián González-Bakker, Aday Mendoza Nozeman, Elisabet Zenaida Padrón, José M. Romerosa Nievas, Antonio Manuel |
| author_sort | Alguacil Alarcón, Andrés |
| collection | DSpace |
| description | [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-N,N’-CuCl}2-μ-Cl-μ-
OCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-
N,N’-NiCl}2-μ-Cl-μ-OH](CF3SO3)2 (2) have been synthesized and
characterized. Their antiproliferative activities were assessed against
six human solid tumours showing nanomolar GI50 values. The effects
of 1 and 2 on SW1573 cells colony formation, HeLa cells action
mechanism and their interaction with the pBR322 DNA plasmid were
evaluated. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-15071 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2024 |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-150712024-01-10T12:32:34Z Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity. Alguacil Alarcón, Andrés Scalambra, Franco Lorenzo Luis, Pablo Puerta, Adrián González-Bakker, Aday Mendoza Nozeman, Elisabet Zenaida Padrón, José M. Romerosa Nievas, Antonio Manuel nanomolar anticancer activity Tetranuclear Ru2Cu2 and Ru2Ni2 complexes [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-N,N’-CuCl}2-μ-Cl-μ- OCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2- N,N’-NiCl}2-μ-Cl-μ-OH](CF3SO3)2 (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI50 values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated. 2024-01-10T12:32:33Z 2024-01-10T12:32:33Z 2023 info:eu-repo/semantics/article http://hdl.handle.net/10835/15071 en Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess Dalton Trans., 2023, 52, 9541–9545, DOI: 10.1039/D3DT01284K |
| spellingShingle | nanomolar anticancer activity Tetranuclear Ru2Cu2 and Ru2Ni2 complexes Alguacil Alarcón, Andrés Scalambra, Franco Lorenzo Luis, Pablo Puerta, Adrián González-Bakker, Aday Mendoza Nozeman, Elisabet Zenaida Padrón, José M. Romerosa Nievas, Antonio Manuel Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity. |
| title | Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity. |
| title_full | Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity. |
| title_fullStr | Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity. |
| title_full_unstemmed | Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity. |
| title_short | Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity. |
| title_sort | tetranuclear ru2cu2 and ru2ni2 complexes with nanomolar anticancer activity. |
| topic | nanomolar anticancer activity Tetranuclear Ru2Cu2 and Ru2Ni2 complexes |
| url | http://hdl.handle.net/10835/15071 |
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