Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives.

Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives.

Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer. 'e evaluated compounds include two new examples...

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Bibliographic Details
Main Authors: Alguacil Alarcón, Andrés, Scalambra, Franco, Romerosa Nievas, Antonio Manuel, Bento-Oliveira, Andreia, Marques, Fernanda, Maximiano, Ines, de Almeida, Rodrigo F. M. Rodrigo, Tomaz, Ana Isabel, Valente, Andreia
Format: info:eu-repo/semantics/article
Language:English
Published: 2024
Subjects:
Antiproliferative Properties of CpRu Complexes
N-Methylated Triazaphosphaadamantane Derivatives
Online Access:http://hdl.handle.net/10835/15072
Description
Summary:Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer. 'e evaluated compounds include two new examples of this family, the complexes [RuCp(DMSO-9S)(HdmoPTA)(PPh3)](CF3SO3)2 (8) and [RuCp(PPh3)2-μ-dmoPTA-19P-292N,N -PdCl2](CF3SO3) (11), which have been synthesized and characterized by NMR, IR, and single-crystal X-ray di@raction.'e cytotoxic activity of compounds was evaluated against MDA-MB-231 breast cancer cells, and the three most active complexes were further tested against the hormone-dependent MCF-7 breast cancer cell line. 'eir cell death mechanism and ruthenium uptake were also evaluated, as well as their binding ability to human serum albumin.

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