Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives.
Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer. 'e evaluated compounds include two new examples...
| Main Authors: | , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10835/15072 |
| _version_ | 1789406404939874304 |
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| author | Alguacil Alarcón, Andrés Scalambra, Franco Romerosa Nievas, Antonio Manuel Bento-Oliveira, Andreia Marques, Fernanda Maximiano, Ines de Almeida, Rodrigo F. M. Rodrigo Tomaz, Ana Isabel Valente, Andreia |
| author_facet | Alguacil Alarcón, Andrés Scalambra, Franco Romerosa Nievas, Antonio Manuel Bento-Oliveira, Andreia Marques, Fernanda Maximiano, Ines de Almeida, Rodrigo F. M. Rodrigo Tomaz, Ana Isabel Valente, Andreia |
| author_sort | Alguacil Alarcón, Andrés |
| collection | DSpace |
| description | Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), N-methyl-1,3,5-triaza-7-phosphaadamantane
(mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer.
'e evaluated compounds include two new examples of this family, the complexes [RuCp(DMSO-9S)(HdmoPTA)(PPh3)](CF3SO3)2
(8) and [RuCp(PPh3)2-μ-dmoPTA-19P-292N,N -PdCl2](CF3SO3) (11), which have been synthesized and characterized by NMR, IR,
and single-crystal X-ray di@raction.'e cytotoxic activity of compounds was evaluated against MDA-MB-231 breast cancer cells, and
the three most active complexes were further tested against the hormone-dependent MCF-7 breast cancer cell line. 'eir cell death
mechanism and ruthenium uptake were also evaluated, as well as their binding ability to human serum albumin. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-15072 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2024 |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-150722024-01-10T12:39:06Z Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives. Alguacil Alarcón, Andrés Scalambra, Franco Romerosa Nievas, Antonio Manuel Bento-Oliveira, Andreia Marques, Fernanda Maximiano, Ines de Almeida, Rodrigo F. M. Rodrigo Tomaz, Ana Isabel Valente, Andreia Antiproliferative Properties of CpRu Complexes N-Methylated Triazaphosphaadamantane Derivatives Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer. 'e evaluated compounds include two new examples of this family, the complexes [RuCp(DMSO-9S)(HdmoPTA)(PPh3)](CF3SO3)2 (8) and [RuCp(PPh3)2-μ-dmoPTA-19P-292N,N -PdCl2](CF3SO3) (11), which have been synthesized and characterized by NMR, IR, and single-crystal X-ray di@raction.'e cytotoxic activity of compounds was evaluated against MDA-MB-231 breast cancer cells, and the three most active complexes were further tested against the hormone-dependent MCF-7 breast cancer cell line. 'eir cell death mechanism and ruthenium uptake were also evaluated, as well as their binding ability to human serum albumin. 2024-01-10T12:39:06Z 2024-01-10T12:39:06Z 2023 info:eu-repo/semantics/article http://hdl.handle.net/10835/15072 en Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess Bioinorganic Chemistry and Applications, 2023, Article ID 6669394, DOI: https://doi.org/10.1155/2023/6669394 |
| spellingShingle | Antiproliferative Properties of CpRu Complexes N-Methylated Triazaphosphaadamantane Derivatives Alguacil Alarcón, Andrés Scalambra, Franco Romerosa Nievas, Antonio Manuel Bento-Oliveira, Andreia Marques, Fernanda Maximiano, Ines de Almeida, Rodrigo F. M. Rodrigo Tomaz, Ana Isabel Valente, Andreia Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives. |
| title | Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives. |
| title_full | Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives. |
| title_fullStr | Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives. |
| title_full_unstemmed | Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives. |
| title_short | Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives. |
| title_sort | evaluation of the antiproliferative properties of cpru complexes containing n-methylated triazaphosphaadamantane derivatives. |
| topic | Antiproliferative Properties of CpRu Complexes N-Methylated Triazaphosphaadamantane Derivatives |
| url | http://hdl.handle.net/10835/15072 |
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