The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)]
Complexes [Ru(η6 C10H14)(Cl2)(HdmoPTA)](OSO2CF3) (1), [Ru(η6 C10H14)(Cl2)(dmoPTA)] (2) and [Ru(η6 C10H14)(Cl2)-μ- dmoPTA-1kP:2k2N,N’-MCl2] (M=Zn (3), Co (4), Ni (5), dmoPTA= 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) have been synthesized and characterized by elemental analysis...
| Main Authors: | , , , , |
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| Format: | info:eu-repo/semantics/article |
| Jezik: | English |
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2024
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| Online dostop: | http://hdl.handle.net/10835/15074 |
| _version_ | 1789406661708873728 |
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| author | Kordestani, Nazanin Abas, Elisa Alguacil Alarcón, Andrés Scalambra, Franco Romerosa Nievas, Antonio Manuel |
| author_facet | Kordestani, Nazanin Abas, Elisa Alguacil Alarcón, Andrés Scalambra, Franco Romerosa Nievas, Antonio Manuel |
| author_sort | Kordestani, Nazanin |
| collection | DSpace |
| description | Complexes [Ru(η6 C10H14)(Cl2)(HdmoPTA)](OSO2CF3)
(1), [Ru(η6 C10H14)(Cl2)(dmoPTA)] (2) and [Ru(η6 C10H14)(Cl2)-μ-
dmoPTA-1kP:2k2N,N’-MCl2] (M=Zn (3), Co (4), Ni (5), dmoPTA=
3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)
have been synthesized and characterized by elemental
analysis and spectroscopic techniques. The crystal structures
of 1, 3 and 5 were obtained by single-crystal X-ray diffraction.
The antiproliferative activity of the complexes was evaluated
against colon cancer cell line Caco-2/TC7 by using the MTT
protocol. The monometallic ruthenium complexes 1 and 2
were found to be inactive, but the bimetallic complexes 3, 4
and 5 display an increased activity (IC50 3: 9.07�0.27, 4:
5.40�0.19, 5: 7.15�0.30 μM) compared to cisplatin (IC50=
45.6�8.08 μM). Importantly, no reduction in normal cell
viability was observed in the presence of the complexes.
Experiments targeted to obtain information on the possible
action mechanism of the complexes, such as cell cycle, ROS
and gene expression studies, were performed. The results
showed that the complexes display different properties and
action mechanism depending on the nature of metal, M,
bonded to the CH3NdmoPTA atoms. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-15074 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2024 |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-150742024-01-10T12:43:51Z The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] Kordestani, Nazanin Abas, Elisa Alguacil Alarcón, Andrés Scalambra, Franco Romerosa Nievas, Antonio Manuel Second Metal Antiproliferative Properties Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] Complexes [Ru(η6 C10H14)(Cl2)(HdmoPTA)](OSO2CF3) (1), [Ru(η6 C10H14)(Cl2)(dmoPTA)] (2) and [Ru(η6 C10H14)(Cl2)-μ- dmoPTA-1kP:2k2N,N’-MCl2] (M=Zn (3), Co (4), Ni (5), dmoPTA= 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) have been synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structures of 1, 3 and 5 were obtained by single-crystal X-ray diffraction. The antiproliferative activity of the complexes was evaluated against colon cancer cell line Caco-2/TC7 by using the MTT protocol. The monometallic ruthenium complexes 1 and 2 were found to be inactive, but the bimetallic complexes 3, 4 and 5 display an increased activity (IC50 3: 9.07�0.27, 4: 5.40�0.19, 5: 7.15�0.30 μM) compared to cisplatin (IC50= 45.6�8.08 μM). Importantly, no reduction in normal cell viability was observed in the presence of the complexes. Experiments targeted to obtain information on the possible action mechanism of the complexes, such as cell cycle, ROS and gene expression studies, were performed. The results showed that the complexes display different properties and action mechanism depending on the nature of metal, M, bonded to the CH3NdmoPTA atoms. 2024-01-10T12:43:51Z 2024-01-10T12:43:51Z 2022 info:eu-repo/semantics/article http://hdl.handle.net/10835/15074 en Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess Inorg. Chem. 2022, 61, 5779−579, DOI: doi.org/10.1021/acs.inorgchem.1c03831 |
| spellingShingle | Second Metal Antiproliferative Properties Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] Kordestani, Nazanin Abas, Elisa Alguacil Alarcón, Andrés Scalambra, Franco Romerosa Nievas, Antonio Manuel The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] |
| title | The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] |
| title_full | The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] |
| title_fullStr | The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] |
| title_full_unstemmed | The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] |
| title_short | The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] |
| title_sort | significant influence of a second metal on the antiproliferative properties of the complex [ru(η6c10h14)(cl2)(dmopta)] |
| topic | Second Metal Antiproliferative Properties Complex [Ru(η6C10H14)(Cl2)(dmoPTA)] |
| url | http://hdl.handle.net/10835/15074 |
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