Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia
Schedule-induced polydipsia (SIP), characterized by the development of persistent and excessive drinking under intermittent food-reinforcement schedules, is an animal model of compulsive behavior that can differentiate two populations: high drinkers (HD) and low drinkers (LD). The aim of the present...
| Main Authors: | , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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2024
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| Online Access: | http://hdl.handle.net/10835/15265 https://doi.org/10.1016/j.pnpbp.2019.03.016 |
| _version_ | 1789406579769999360 |
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| author | Merchán Carrillo, Ana María Sánchez Kuhn, Ana Prados Pardo, Ángeles Gago Calderón, Belén Sánchez Santed, Luis Fernando Moreno Montoya, Margarita Begoña Flores Cubos, María Del Pilar |
| author_facet | Merchán Carrillo, Ana María Sánchez Kuhn, Ana Prados Pardo, Ángeles Gago Calderón, Belén Sánchez Santed, Luis Fernando Moreno Montoya, Margarita Begoña Flores Cubos, María Del Pilar |
| author_sort | Merchán Carrillo, Ana María |
| collection | DSpace |
| description | Schedule-induced polydipsia (SIP), characterized by the development of persistent and excessive drinking under intermittent food-reinforcement schedules, is an animal model of compulsive behavior that can differentiate two populations: high drinkers (HD) and low drinkers (LD). The aim of the present study was to identify behavioral and biological markers to predict the vulnerability to developing compulsive-like drinking in SIP. Adult male Wistar rats were first trained in a spatial-discrimination serial reversal-learning task and in a reinforcer devaluation task to measure behavioral flexibility and habit formation, respectively. Subsequently, the rats were tested using the SIP protocol and identified as HD or LD based on their drinking rates. The performance of HD and LD rats in the two previous tasks was then analyzed. Before and after SIP exposure, blood glucose and plasma corticosterone (CORT) levels were measured. Additionally, serum electrolyte levels, including sodium, potassium, and chloride, were analyzed after SIP. HD rats showed higher behavioral inflexibility by exhibiting increased perseverative responses in the reversal-learning task and insensitivity to reinforcer devaluation during extinction under selective satiation. After SIP exposure, HD rats exhibited increased basal plasma CORT levels, indicating that this vulnerable group might have a dysregulation of the HPA axis. Although HD and LD rats had blood glucose levels within normal range, the HD group showed lower levels. The HD group did not exhibit hyponatremia (i.e., reduced serum sodium levels) when compared to LD rats after 20 daily SIP sessions. The results of the present study demonstrated that HD rats exhibit behavioral inflexibility and greater habitual-like behavior before SIP. Moreover, these results highlight the importance of measuring different behavioral and biological markers for predicting the vulnerability to developing compulsivity, and for enhancing the understanding of the pathophysiology of compulsive spectrum disorders. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-15265 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2024 |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-152652024-01-19T13:23:23Z Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia Merchán Carrillo, Ana María Sánchez Kuhn, Ana Prados Pardo, Ángeles Gago Calderón, Belén Sánchez Santed, Luis Fernando Moreno Montoya, Margarita Begoña Flores Cubos, María Del Pilar Schedule-induced Polydipsia Compulsivity Reversal Learning Reinforcer Devaluation Corticosterone Schedule-induced polydipsia (SIP), characterized by the development of persistent and excessive drinking under intermittent food-reinforcement schedules, is an animal model of compulsive behavior that can differentiate two populations: high drinkers (HD) and low drinkers (LD). The aim of the present study was to identify behavioral and biological markers to predict the vulnerability to developing compulsive-like drinking in SIP. Adult male Wistar rats were first trained in a spatial-discrimination serial reversal-learning task and in a reinforcer devaluation task to measure behavioral flexibility and habit formation, respectively. Subsequently, the rats were tested using the SIP protocol and identified as HD or LD based on their drinking rates. The performance of HD and LD rats in the two previous tasks was then analyzed. Before and after SIP exposure, blood glucose and plasma corticosterone (CORT) levels were measured. Additionally, serum electrolyte levels, including sodium, potassium, and chloride, were analyzed after SIP. HD rats showed higher behavioral inflexibility by exhibiting increased perseverative responses in the reversal-learning task and insensitivity to reinforcer devaluation during extinction under selective satiation. After SIP exposure, HD rats exhibited increased basal plasma CORT levels, indicating that this vulnerable group might have a dysregulation of the HPA axis. Although HD and LD rats had blood glucose levels within normal range, the HD group showed lower levels. The HD group did not exhibit hyponatremia (i.e., reduced serum sodium levels) when compared to LD rats after 20 daily SIP sessions. The results of the present study demonstrated that HD rats exhibit behavioral inflexibility and greater habitual-like behavior before SIP. Moreover, these results highlight the importance of measuring different behavioral and biological markers for predicting the vulnerability to developing compulsivity, and for enhancing the understanding of the pathophysiology of compulsive spectrum disorders. 2024-01-19T13:23:23Z 2024-01-19T13:23:23Z 2019-03-30 info:eu-repo/semantics/article Merchán, A., Sánchez-Kuhn, A., Prados-Pardo, Á., Gago, B., Sánchez-Santed, F., Moreno, M., & Flores, P. (2019c). Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93, 149-160. https://doi.org/10.1016/j.pnpbp.2019.03.016 02785846 http://hdl.handle.net/10835/15265 https://doi.org/10.1016/j.pnpbp.2019.03.016 en PSI2017-86847-C2-1-R Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| spellingShingle | Schedule-induced Polydipsia Compulsivity Reversal Learning Reinforcer Devaluation Corticosterone Merchán Carrillo, Ana María Sánchez Kuhn, Ana Prados Pardo, Ángeles Gago Calderón, Belén Sánchez Santed, Luis Fernando Moreno Montoya, Margarita Begoña Flores Cubos, María Del Pilar Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia |
| title | Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia |
| title_full | Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia |
| title_fullStr | Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia |
| title_full_unstemmed | Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia |
| title_short | Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia |
| title_sort | behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia |
| topic | Schedule-induced Polydipsia Compulsivity Reversal Learning Reinforcer Devaluation Corticosterone |
| url | http://hdl.handle.net/10835/15265 https://doi.org/10.1016/j.pnpbp.2019.03.016 |
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