Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial
This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | English |
| Published: |
MDPI
2020
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10835/7536 |
| _version_ | 1789406584703549440 |
|---|---|
| author | Soriano Maldonado, Alberto Morillas de Laguno, Pablo Sabio, José Mario Gavilán Carrera, Blanca Rosales Castillo, Antonio Montalbán Méndez, Cristina Sáez Urán, Luis Manuel Callejas Rubio, José Luis Vargas Hitos, José Antonio |
| author_facet | Soriano Maldonado, Alberto Morillas de Laguno, Pablo Sabio, José Mario Gavilán Carrera, Blanca Rosales Castillo, Antonio Montalbán Méndez, Cristina Sáez Urán, Luis Manuel Callejas Rubio, José Luis Vargas Hitos, José Antonio |
| author_sort | Soriano Maldonado, Alberto |
| collection | DSpace |
| description | This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions × 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN-α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference −0.034, 95% CI −0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-7536 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-75362023-04-12T19:14:16Z Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial Soriano Maldonado, Alberto Morillas de Laguno, Pablo Sabio, José Mario Gavilán Carrera, Blanca Rosales Castillo, Antonio Montalbán Méndez, Cristina Sáez Urán, Luis Manuel Callejas Rubio, José Luis Vargas Hitos, José Antonio exercise physical fitness aerobic fitness physical function pulse wave velocity autoimmune diseases vascular health atherosclerosis lupus inflammatory disease This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions × 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN-α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference −0.034, 95% CI −0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE. 2020-01-17T09:59:52Z 2020-01-17T09:59:52Z 2018-11-24 info:eu-repo/semantics/article 2077-0383 http://hdl.handle.net/10835/7536 en https://www.mdpi.com/2077-0383/7/12/477 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | exercise physical fitness aerobic fitness physical function pulse wave velocity autoimmune diseases vascular health atherosclerosis lupus inflammatory disease Soriano Maldonado, Alberto Morillas de Laguno, Pablo Sabio, José Mario Gavilán Carrera, Blanca Rosales Castillo, Antonio Montalbán Méndez, Cristina Sáez Urán, Luis Manuel Callejas Rubio, José Luis Vargas Hitos, José Antonio Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial |
| title | Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial |
| title_full | Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial |
| title_fullStr | Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial |
| title_full_unstemmed | Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial |
| title_short | Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial |
| title_sort | effects of 12-week aerobic exercise on arterial stiffness, inflammation, and cardiorespiratory fitness in women with systemic lupus erythematosus: non-randomized controlled trial |
| topic | exercise physical fitness aerobic fitness physical function pulse wave velocity autoimmune diseases vascular health atherosclerosis lupus inflammatory disease |
| url | http://hdl.handle.net/10835/7536 |
| work_keys_str_mv | AT sorianomaldonadoalberto effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial AT morillasdelagunopablo effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial AT sabiojosemario effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial AT gavilancarrerablanca effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial AT rosalescastilloantonio effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial AT montalbanmendezcristina effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial AT saezuranluismanuel effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial AT callejasrubiojoseluis effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial AT vargashitosjoseantonio effectsof12weekaerobicexerciseonarterialstiffnessinflammationandcardiorespiratoryfitnessinwomenwithsystemiclupuserythematosusnonrandomizedcontrolledtrial |