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2by Alfaro, C. (Carlos), Suarez, N. (Natalia), Oñate, C. (Carmen), Perez-Gracia, J.L. (Jose Luis), Martinez-Forero, I. (Iván), Hervas-Stubbs, S. (Sandra), Rodriguez, I. (Inmaculada), Perez, G. (Guiomar), Bolaños, E. (Elixabet), Palazon, A. (Asís), Fernandez-Sanmamed, M. (Miguel), Morales-Kastresana, A. (Aizea), Gonzalez-Hernandez, A. (Alvaro), Melero, I. (Ignacio)Subjects: “…Dendritic cells…”
Published 2012
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3by Martirosyan, A. (Anna), Perez-Gutierrez, C. (Camino), Banchereau, R. (Romain), Dutartre, H. (Hélène), Lecine, P. (Patrick), Dullaers, M. (Melissa), Mello, M. (Marielle), Pinto, S. (Suzana), Muller, A. (Alexandre), Leserman, L. (Lee), Levy, Y. (Yves), Zurawski, G. (Gerard), Zurawski, S. (Sandy), Moreno, E. (Edgardo), Moriyon, I. (Ignacio), Klechesvky, E. (Eynav), Banchereau, J. (Jacques), Oh, S. (SangKon), Gorvel, J.P. (Jean Pierre)“…Here, we demonstrate that Brucella beta 1,2 cyclic glucans are potent activators of human and mouse dendritic cells. Dendritic cells activation by Brucella beta 1,2 cyclic glucans requires TLR4, MyD88 and TRIF, but not CD14. …”
Published 2013
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4by Zhao, Y. (Yun), Hanniffy, S. (Sean), Arce-Gorvel, V. (Vilma), Conde-Alvarez, R. (Raquel), Oh, S. (SangKon), Moriyon, I. (Ignacio), Mémet, S. (Sylvie), Gorvel, J.P. (Jean Pierre)Subjects: Get full text
Published 2023
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5by Martirosyan, A. (Anna), Ohne, Y. (Yoichiro), Degos, C. (Clara), Gorvel, L. (Laurent), Moriyon, I. (Ignacio), Oh, S. (SangKon), Gorvel, J.P. (Jean Pierre)Subjects: Get full text
Published 2013
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6by Camacho, A.I. (A.I.), Raquel, Tamayo, I. (Ibai), Souza, J. (Juliana) de, Lasarte, J.J. (Juan José), Mansilla, C. (Cristina), Esparza, I. (Irene), Irache, J.M. (Juan Manuel), Gamazo, C. (Carlos)“…In previous studies it was demonstrated that poly(methyl vinyl ether-co-maleic anhydride) nanoparticles (PVMA NPs) used as adjuvant differentially activate dendritic cells through toll like receptors (TLR) stimulation, however, a high dose of these NPs was used. …”
Published 2011
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7The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognitionby Raquel, Arce-Gorvel, V. (Vilma), Iriarte, M. (Maite), Mancek-Keber, M. (Mateja), Barquero-Calvo, E. (Elías), Palacios-Chaves, L. (Leyre), Chacon-Diaz, C. (Carlos), Chaves-Olarte, E. (Esteban), Martirosyan, A. (Anna), Bargen, K. (Kristine) von, Grillo, M.J. (María Jesús), Jerala, R. (Roman), Brandenburg, K. (Klaus), Llobet, E. (Enrique), Bengoechea, J.A. (José A.), Moreno, E. (Edgardo), Moriyon, I. (Ignacio), Gorvel, J.P. (Jean Pierre)“…In contrast to wild type B. abortus, the wadC mutant induced dendritic cell maturation and secretion of pro-inflammatory cytokines. …”
Published 2013
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8“…The cycle starts with the release of neoantigens by the cancer cells which are captured by the dendritic cells (DCs) for processing. DCs migrate to lymph nodes where they present processed antigens to T cells, activating effector T cell responses. …”
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9by Gil-Ramirez, Y. (Yolanda), Raquel, Palacios-Chaves, L. (Leyre), Zuñiga-Ripa, A. (Amaia), Grillo, M.J. (María Jesús), Arce-Gorvel, V. (Vilma), Hanniffy, S. (Sean), Moriyon, I. (Ignacio), Iriarte, M. (Maite)“…As compared to wild-type B. abortus, a wadB mutant was sensitive to bactericidal peptides and non-immune serum, and was attenuated in mice and dendritic cells. These observations show that as WadC, WadB is also involved in the assembly of a branch of Brucella LPS core and support the concept that this LPS section is a virulence-related structure.…”
Published 2019
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10“…Broadly speaking, specialized blood cells can carry out four main functions: 1) The innate immune system, composed, among others, by macrophages, dendritic cells and granulocytes, constitutes the first defense against infection 2) The adaptive immune system, composed by B and T lymphocytes, carries out a delayed and specialized response against pathogens. 3) Red blood cells transport oxygen to every cell 4) Platelets take care of wound healing.…”
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11by Tamayo, I. (Ibai), Irache, J.M. (Juan Manuel), Mansilla, C. (Cristina), Ochoa-Repáraz, J. (Javier), Lasarte, J.J. (Juan José), Gamazo, C. (Carlos)“…Our results revealed that poly(anhydride) NPs also act as agonists of various Toll-like receptors (TLRs) (TLR2, -4, and -5), triggering a Th1-profile cytokine release (gamma interferon [IFN- ], 478 pg/ml versus 39.6 pg/ml from negative control; interleukin-12 [IL-12], 40 pg/ml versus 7.2 pg/ml from negative control) and, after incubation with dendritic cells, inducing a 2.5- to 3.5-fold increase of CD54 and CD86 costimulatory molecule expression. …”
Published 2011
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12by Barquero-Calvo, E. (Elías), Raquel, Chacon-Diaz, C. (Carlos), Quesada-Lobo, L. (Lucía), Martirosyan, A. (Anna), Guzman-Verri, C. (Caterina), Iriarte, M. (Maite), Mancek-Keber, M. (Mateja), Jerala, R. (Roman), Gorvel, J.P. (Jean Pierre), Moriyon, I. (Ignacio), Moreno, E. (Edgardo), Chaves-Olarte, E. (Esteban)“…O. anthropi triggered proinflammatory responses markedly lower than Salmonella enterica but higher than B. abortus. In macrophages and dendritic cells, the corresponding lipopolysaccharides reproduced these grades of activation, and binding of O. anthropi lipopolysaccharide to the TLR4 co-receptor MD-2 and NF-kappaB induction laid between those of B. abortus and enteric bacteria lipopolysaccharides. …”
Published 2013
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13by Puigdelloses-Vallcorba, M. (Montserrat), Alonso-Roldán, M.M. (Marta María), Gallego-Perez-Larraya, J. (Jaime)“…In order to improve the survival and to generate immune memory, we combined the virus with different immune modulating approaches (dendritic cell vaccination, IDO inhibitor, macrophages inhibitor etc). …”
Published 2021
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14“…Activated T lymphocytes, natural killer cells, dendritic cells and pro-inflammatory macrophages account for the majority of the inflammatory infiltrate and contribute in the hepatic expression of TGF-β, ISG15, ADAR-1, IP10, PKR, and USP18. …”
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15“…CM-414 reversed cognitive impairment, reduced amyloid and tau pathology, and rescued dendritic spine density loss in the hippocampus in AD mice. …”
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16“…Moreover, the predictive validity of the model has been poorly analyzed let alone the possible alterations in dendritic and synaptic structures of brain regions involved in emotional processing. …”
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