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“…We used available data from previous microarray studies, which compared gene expression between normal and lung cancer tissues. …”
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“…In this work we have analyzed the transcriptional changes produced in Brucella by erythritol by means of two high throughput approaches: RNA hybridization against a microarray containing most of Brucella ORF's constructed from the Brucella ORFeome and next generation sequencing of Brucella mRNA in an Illumina GAIIx platform. …”
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“…To determine the genes regulated by BvrR/BvrS, we performed a whole-genome microarray analysis using B. abortus RNA obtained from wild type and bvrR mutant cells grown in the same conditions. …”
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“…Moreover, a Chromatin immunoprecipitation (ChIP) assay demonstrated that HIF-1 directly binds to the hypoxia response element identified in mouse Cav-1 promoter (-442 TSS) by bioinformatics analysis. A microarray of gene expression was also performed to explore new genes implicated in hypoxia response of 3T3-L1 adipocytes. …”
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“…In order to deepen into the mechanisms implicated we carried out magnetic resonance and plasma biochemical analysis, as well as transcriptomic (microarray and RT-qPCR) and DNA methylation-based techniques (mass spectrometry and radioactivity-related), among others. …”
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“…In the laboratory, they had performed transcriptome studies of control cells, cells infected with Hepatitis C virus (HCV) and/or cells treated with IFN-alpha by microarray and RNA sequencing. They found that IFN-alpha-treatment and/or HCV infection alters the levels of several lncRNAs. …”
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“…In chapter 2, after combining methylation and expression microarrays data, we observed that miR-612 and miR-1976 were hypomethylated and overexpressed in high responders to a weight loss intervention. …”
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“…In this context, this research work has taken advantage of omics and high-throughput screening technologies in order to address the following aims: 1) to analyse the association between DNA methylation in white blood cells and the development of obesity in a pediatric population; 2) to investigate the influence of a weight loss intervention in the DNA methylation levels of genes involved in the circadian system, and the association between DNA methylation and changes in the lipid profile; 3) to identify potential epigenetic biomarkers for weight loss within a weight-loss program by integrating transcriptome and methylome microarray data; 4) to evaluate whether a low intake of folic acid is related to adverse metabolic features in obese subjects through changes in gene-specific DNA methylation pattern, and 5) to study whether folic acid and other dietary methyl donors can prevent the inflammatory response in an in vitro model through epigenetic mechanisms. …”
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“…Therefore, we have searched for novel fusion genes search using a new methodology based on exon microarrays.…”
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“…c) Análisis de su capacidad de diferenciación a los principales linajes neurales presentes en el SNC. 2 - Validación de un modelo de inducción de la diferenciación in vitro de las neuroesferas (o BTSCs) en presencia de factores de crecimiento. 3 - Análisis de la expresión global de miRNAs durante el proceso de diferenciación in vitro de las BTSCs de GBM mediante microarrays de miRNAs. 4 - Estudio de la implicación funcional de los miRNAs validados y seleccionados en la diferenciación in vitro de las BTSCs de GBM. …”
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“…Whole tumour sections and tissue microarrays from patients with non-small cell lung cancer (NSCLC; n = 14), bladder cancer (n = 14), melanoma (n = 11), breast cancer (n = 31), colorectal cancer (n = 20) and mesothelioma (n = 61) were studied. …”
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“…Se realizó un estudio de la metilación del DNA en NPMC mediante microarrays de metilación. En la primera parte, se estudió la metilación del DNA mediante el array Illumina Infinium® 27k en muestras de PV, ET, MFP y transformaciones a LMA; en la segunda parte, se estudió la mielofibrosis (MF) tanto primaria como secundaria, utilizando el array de Illumina Infinium® 450K (segunda generación). …”
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