Nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies
Edelfosine is a synthetic alkyl ether phospholipid that represents a promising class of antitumor agents, with limited side effects but presenting a low oral bioavailability. In order to solve this drawback, edelfosine has been entrapped into lipid nanoparticles (LN). The nanosystems have been prep...
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Language: | eng |
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Servicio de Publicaciones de la Universidad de Navarra
2011
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/17631 |
| _version_ | 1793400583678328832 |
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| author | Estella-Hermoso-de-Mendoza, A. (Ander) Blanco-Prieto, M.J. (María José) |
| author_facet | Estella-Hermoso-de-Mendoza, A. (Ander) Blanco-Prieto, M.J. (María José) |
| author_sort | Estella-Hermoso-de-Mendoza, A. (Ander) |
| collection | DSpace |
| description | Edelfosine is a synthetic alkyl ether phospholipid that represents a promising class of antitumor agents, with limited side effects but presenting a low oral bioavailability. In order to solve this drawback, edelfosine has been entrapped into lipid nanoparticles (LN). The nanosystems have been prepared by the Hot Homogenization technique, which does not require the use of organic solvents, thus reducing toxicity issues. The developed LN had a size of 100 nm, suitable for oral administration, with an encapsulation efficiency up to 90 %. The LN orally administered to mice were mainly absorbed through the lymphatic system and increased by 1500 % the oral bioavailability of the drug. Besides, these nanoparticles significantly increased the drug concentration in the brain due to the inhibition of the blood brain barrier P-glycoprotein. The developed LN were tested against mantle cell lymphoma and glioma xenograft animal models. Mice were treated orally with a solution of edelfosine and with edelfosine loaded LN. Results showed that edelfosine loaded LN were significantly more effective than the oral solution of the drug in both tumor models. Moreover, no metastases were observed in mice treated with the LN, while the edelfosine solution was not able to eliminate the metastatization process. In conclusion, these LN appear to be promising systems for the future therapy of cancer. |
| format | info:eu-repo/semantics/doctoralThesis |
| id | oai:dadun.unav.edu:10171-17631 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2011 |
| publisher | Servicio de Publicaciones de la Universidad de Navarra |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-176312020-03-23T17:31:40Z Nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies Estella-Hermoso-de-Mendoza, A. (Ander) Blanco-Prieto, M.J. (María José) Edelfosine Lipid nanoparticles Bioavailability lymphoma Glioma Edelfosine is a synthetic alkyl ether phospholipid that represents a promising class of antitumor agents, with limited side effects but presenting a low oral bioavailability. In order to solve this drawback, edelfosine has been entrapped into lipid nanoparticles (LN). The nanosystems have been prepared by the Hot Homogenization technique, which does not require the use of organic solvents, thus reducing toxicity issues. The developed LN had a size of 100 nm, suitable for oral administration, with an encapsulation efficiency up to 90 %. The LN orally administered to mice were mainly absorbed through the lymphatic system and increased by 1500 % the oral bioavailability of the drug. Besides, these nanoparticles significantly increased the drug concentration in the brain due to the inhibition of the blood brain barrier P-glycoprotein. The developed LN were tested against mantle cell lymphoma and glioma xenograft animal models. Mice were treated orally with a solution of edelfosine and with edelfosine loaded LN. Results showed that edelfosine loaded LN were significantly more effective than the oral solution of the drug in both tumor models. Moreover, no metastases were observed in mice treated with the LN, while the edelfosine solution was not able to eliminate the metastatization process. In conclusion, these LN appear to be promising systems for the future therapy of cancer. 2011-04-09T09:07:34Z 2011-04-09T09:07:34Z 2011 2011-03-24 info:eu-repo/semantics/doctoralThesis https://hdl.handle.net/10171/17631 eng info:eu-repo/semantics/openAccess application/pdf Servicio de Publicaciones de la Universidad de Navarra |
| spellingShingle | Edelfosine Lipid nanoparticles Bioavailability lymphoma Glioma Estella-Hermoso-de-Mendoza, A. (Ander) Blanco-Prieto, M.J. (María José) Nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies |
| title | Nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies |
| title_full | Nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies |
| title_fullStr | Nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies |
| title_full_unstemmed | Nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies |
| title_short | Nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies |
| title_sort | nanosystems for the oral administration of alkyl-lysophospholipid anti-tumor agents: development of lipid nanotransporters and preclinical studies |
| topic | Edelfosine Lipid nanoparticles Bioavailability lymphoma Glioma |
| url | https://hdl.handle.net/10171/17631 |
| work_keys_str_mv | AT estellahermosodemendozaaander nanosystemsfortheoraladministrationofalkyllysophospholipidantitumoragentsdevelopmentoflipidnanotransportersandpreclinicalstudies AT blancoprietomjmariajose nanosystemsfortheoraladministrationofalkyllysophospholipidantitumoragentsdevelopmentoflipidnanotransportersandpreclinicalstudies |