3-Trifluoromethylquinoxaline N,N’-Dioxides as Anti-trypanosomatid Agents. Identification of Optimal Anti-T. cruzi Derivatives and Mechanism of Action Studies

3-Trifluoromethylquinoxaline N,N’-Dioxides as Anti-trypanosomatid Agents. Identification of Optimal Anti-T. cruzi Derivatives and Mechanism of Action Studies

As a fourth approach of quinoxaline N,N’-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti-T. cruzi activity. Derivatives possessing electron...

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Bibliographic Details
Main Authors: Benitez, D. (Diego), Cabrera, M. (Mauricio), Hernández, P. (Paola), Boiani, L. (L.), Lavaggi, M.L. (María L.), Di-Maio, R. (Rossanna), Yaluff, G. (Gloria), Serna, E. (Elva), Torres, E. (Enrique), Ferreira, M.E. (María E.), Vera-De-Bilbao, N. (Ninfa), Pérez-Silanes, S. (Silvia), Solano, B. (Beatriz), Moreno-de-Viguri, E. (Elsa), Aldana, I. (Ignacio), Lopez-de-Cerain, A. (Adela), Cerecetto, H. (Hugo), Gonzalez, M. (Mercedes), Monge, A. (Antonio)
Format: info:eu-repo/semantics/article
Language:eng
Published: American Chemical Society 2011
Subjects:
Quinoxaline N,N´-Dioxide
T. cruzi
Leishmania
Online Access:https://hdl.handle.net/10171/18725

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https://hdl.handle.net/10171/18725

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