Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships

Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships

Piperazine and pyrrolidine derivatives were synthesized and evaluated for their capacity to inhibit the growth of Plasmodium falciparum chloroquine-resistant (FCR-3) strain in culture. The combined presence of a hydroxyl group, a propane chain and a fluor were shown to be crucial for the antiplasmod...

Full description

Bibliographic Details
Main Authors: Mendoza, A. (Adela), Pérez-Silanes, S. (Silvia), Quiliano, M. (Miguel), Pabon, A. (Adriana), Gonzalez, G. (Germán), Garavito, G. (Giovanny), Zimic, M. (Mirko), Vaisberg, A. (Abrahm), Aldana, I. (Ignacio), Monge, A. (Antonio), Deharo, E. (Eric)
Format: info:eu-repo/semantics/article
Language:eng
Published: Elsevier 2011
Subjects:
Piperazine
Pyrrolidine
Antiplasmodial
Plasmodium
Antimalarial agents
Docking studies
Online Access:https://hdl.handle.net/10171/18730

Internet

https://hdl.handle.net/10171/18730

Similar Items