Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships
Piperazine and pyrrolidine derivatives were synthesized and evaluated for their capacity to inhibit the growth of Plasmodium falciparum chloroquine-resistant (FCR-3) strain in culture. The combined presence of a hydroxyl group, a propane chain and a fluor were shown to be crucial for the antiplasmod...
| Main Authors: | , , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Elsevier
2011
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/18730 |