Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death
The antiphospholipid syndrome (APS) is associated with thrombosis and fetal death but the pathologic mechanisms are poorly understood. Since endothelial protein C receptor (EPCR) plays a role in the anticoagulant system and in placental development, we hypothesized that anti-EPCR autoantibodies may...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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American Society of Hematology
2012
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| Online Access: | https://hdl.handle.net/10171/22273 |
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| author | Hurtado, V. (Verónica) Montes, R. (Ramón) Gris, J.C. (Jean-Christophe) Bertolaccini, M.L. (María L.) Alonso, A. (Alvaro) Martinez-Gonzalez, M.A. (Miguel Ángel) Khamashta, M.A. (Munther A.) Fukudome, K. (Kenji) Lane, D.A. (David A.) Hermida, J. (José) |
| author_facet | Hurtado, V. (Verónica) Montes, R. (Ramón) Gris, J.C. (Jean-Christophe) Bertolaccini, M.L. (María L.) Alonso, A. (Alvaro) Martinez-Gonzalez, M.A. (Miguel Ángel) Khamashta, M.A. (Munther A.) Fukudome, K. (Kenji) Lane, D.A. (David A.) Hermida, J. (José) |
| author_sort | Hurtado, V. (Verónica) |
| collection | DSpace |
| description | The antiphospholipid syndrome (APS) is associated with thrombosis and fetal death but the pathologic mechanisms are poorly understood. Since endothelial protein C receptor (EPCR) plays a role in the anticoagulant system and in placental development, we hypothesized that anti-EPCR autoantibodies may be involved in clinical manifestations of APS and in fetal loss. The levels of immunoglobulin M (IgM) and IgG anti-EPCR autoantibodies were analyzed by enzyme-linked immunosorbent assay (ELISA) in 43 patients with APS and 43 controls. Anti-EPCR levels were higher in APS patients than in controls. Interestingly, one of the IgM anti-EPCR autoantibodies inhibited the generation of activated protein C on endothelium. Since markedly high anti-EPCR levels were found in women with fetal death, 87 patients with a first episode of unexplained fetal death were subsequently analyzed and their anti-EPCR levels were compared with 87 matched controls. We found that anti-EPCR autoantibodies constitute an independent risk factor for a first fetal death episode: the adjusted odds ratios (ORs) for anti-EPCR autoantibodies above the 95th percentile were 23.0 (95% confidence interval [CI], 2.0-266.3) for IgM and 6.8 (95% CI, 1.2-38.4) for IgG. Anti-EPCR autoantibodies can be detected in APS patients and are independent risk factors for fetal death. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-22273 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | American Society of Hematology |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-222732022-06-29T09:41:38Z Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death Hurtado, V. (Verónica) Montes, R. (Ramón) Gris, J.C. (Jean-Christophe) Bertolaccini, M.L. (María L.) Alonso, A. (Alvaro) Martinez-Gonzalez, M.A. (Miguel Ángel) Khamashta, M.A. (Munther A.) Fukudome, K. (Kenji) Lane, D.A. (David A.) Hermida, J. (José) Antiphospholipid syndrome/immunology Autoantibodies/blood Endothelins/immunology Fetal death/immunology Pregnancy complications/immunology The antiphospholipid syndrome (APS) is associated with thrombosis and fetal death but the pathologic mechanisms are poorly understood. Since endothelial protein C receptor (EPCR) plays a role in the anticoagulant system and in placental development, we hypothesized that anti-EPCR autoantibodies may be involved in clinical manifestations of APS and in fetal loss. The levels of immunoglobulin M (IgM) and IgG anti-EPCR autoantibodies were analyzed by enzyme-linked immunosorbent assay (ELISA) in 43 patients with APS and 43 controls. Anti-EPCR levels were higher in APS patients than in controls. Interestingly, one of the IgM anti-EPCR autoantibodies inhibited the generation of activated protein C on endothelium. Since markedly high anti-EPCR levels were found in women with fetal death, 87 patients with a first episode of unexplained fetal death were subsequently analyzed and their anti-EPCR levels were compared with 87 matched controls. We found that anti-EPCR autoantibodies constitute an independent risk factor for a first fetal death episode: the adjusted odds ratios (ORs) for anti-EPCR autoantibodies above the 95th percentile were 23.0 (95% confidence interval [CI], 2.0-266.3) for IgM and 6.8 (95% CI, 1.2-38.4) for IgG. Anti-EPCR autoantibodies can be detected in APS patients and are independent risk factors for fetal death. 2012-05-28T15:58:37Z 2012-05-28T15:58:37Z 2004 info:eu-repo/semantics/article https://hdl.handle.net/10171/22273 eng http://bloodjournal.hematologylibrary.org/content/104/5/1369 info:eu-repo/semantics/openAccess application/pdf American Society of Hematology |
| spellingShingle | Antiphospholipid syndrome/immunology Autoantibodies/blood Endothelins/immunology Fetal death/immunology Pregnancy complications/immunology Hurtado, V. (Verónica) Montes, R. (Ramón) Gris, J.C. (Jean-Christophe) Bertolaccini, M.L. (María L.) Alonso, A. (Alvaro) Martinez-Gonzalez, M.A. (Miguel Ángel) Khamashta, M.A. (Munther A.) Fukudome, K. (Kenji) Lane, D.A. (David A.) Hermida, J. (José) Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death |
| title | Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death |
| title_full | Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death |
| title_fullStr | Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death |
| title_full_unstemmed | Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death |
| title_short | Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death |
| title_sort | autoantibodies against epcr are found in antiphospholipid syndrome and are a risk factor for fetal death |
| topic | Antiphospholipid syndrome/immunology Autoantibodies/blood Endothelins/immunology Fetal death/immunology Pregnancy complications/immunology |
| url | https://hdl.handle.net/10171/22273 |
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