Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease
Abstract BACKGROUND AND PURPOSE: Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the pathological features of Alzhe...
| Main Authors: | , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Wiley-Blackwell
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/22826 |