Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease
Abstract BACKGROUND AND PURPOSE: Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the pathological features of Alzhe...
Main Authors: | Garcia-Osta, A. (Ana), Aguirre, N. (Norberto), Franco, R. (Rafael), Garcia-Barroso, C. (C.), Perez-Roldan, J.M. (J.M.), Puerta, E. (Elena), Ricobaraza, A. (Ana), Hervias, I. (Isabel), Cuadrado-Tejedor, M. (Mar) |
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Format: | info:eu-repo/semantics/article |
Language: | eng |
Published: |
Wiley-Blackwell
2012
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Subjects: | |
Online Access: | https://hdl.handle.net/10171/22826 |
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