New 1-aryl-3-substituted propanol derivatives as antimalarial agents

New 1-aryl-3-substituted propanol derivatives as antimalarial agents

This paper describes the synthesis and in vitro antimalarial activity against a P. falciparum 3D7 strain of some new 1-aryl-3-substituted propanol derivatives. Twelve of the tested compounds showed an IC50 lower than 1 μM. These compounds were also tested for cytotoxicity in murine J774 macrophag...

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Bibliographic Details
Main Authors: Pérez-Silanes, S. (Silvia), Berrade, L. (Luis), Garcia–Sanchez, R.N. (Rory N.), Mendoza, A. (Adela), Galiano, S. (Silvia), Martin-Perez-Solorzano, B. (Berta), Nogal-Ruiz, J.J. (Juan J.), Martinez-Fernandez, A.R. (Antonio R.), Aldana, I. (Ignacio), Monge, A. (Antonio)
Format: info:eu-repo/semantics/article
Language:eng
Published: MDPI 2012
Subjects:
Antimalarial agents
Benzo(b)thiophene
1-aryl-3-substituted propanol derivatives
P. Falciparum
Ferriprotoporphyrin
Online Access:https://hdl.handle.net/10171/23600

Internet

https://hdl.handle.net/10171/23600

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