Novel phenazine 5,10-dioxides release OH in simulated hypoxia and induce reduction of tumour volume in vivo

Novel phenazine 5,10-dioxides release OH in simulated hypoxia and induce reduction of tumour volume in vivo

Phenazine 5,10-dioxides (PDOs) are a new class of bioreductive cytotoxins, which could act towards tumours containing hypoxic regions. The PDOs selective-hypoxic bioreduction was probed in vitro; however, the mechanism of action has not been completely explained. Besides, PDOs in vivo antitumour act...

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Bibliographic Details
Main Authors: Lavaggi, M.L. (María L.), Cabrera, M. (Mauricio), Pintos, C. (Cristina), Pérez-Arredondo, C. (Carolina), Pachon, G. (Gisela), Rodríguez, J. (Jorge), Raymondo, S. (Stella), Pacheco, J.P. (José Pedro), Cascante, M. (Marta), Olea-Azar, C. (Claudio), Lopez-de-Cerain, A. (Adela), Monge, A. (Antonio), Cerecetto, H. (Hugo), Gonzalez, M. (Mercedes)
Format: info:eu-repo/semantics/article
Language:eng
Published: Hindawi Publishing Corporation 2013
Subjects:
Cytotoxins
Therapeutic
Cancer
Hypoxia
Online Access:https://hdl.handle.net/10171/27871

Internet

https://hdl.handle.net/10171/27871

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