Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides

Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides

Bacterial endotoxins (lipopolysaccharides (LPS)) are strong elicitors of the human immune system by interacting with serum and membrane proteins such as lipopolysaccharide-binding protein (LBP) and CD14 with high specificity. At LPS concentrations as low as 0.3 ng/ml, such interactions may lead to s...

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Bibliographic Details
Main Authors: Kaconis, Y. (Yani), Kowalski, I. (Ina), Howe, J. (Jörg), Brauser, A. (Annemarie), Richter, W. (Walter), Razquin-Olazaran, I. (Iosu), Iñigo, M. (Melania), Garidel, P. (Patrick), Rossle, M. (Manfred), Martinez-de-Tejada, G. (Guillermo), Gutsmann, T. (Thomas), Brandenburg, K. (Klaus)
Format: info:eu-repo/semantics/article
Language:eng
Published: Cell Press (Elsevier) 2013
Subjects:
Antimicrobial cationic peptides chemistry
Antimicrobial cationic peptides metabolism
Biophysical processes
Hydrophobic and hydrophilic interactions
Lipopolysaccharides metabolism
Female
Online Access:https://hdl.handle.net/10171/29503

Internet

https://hdl.handle.net/10171/29503

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