Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation
MD-2 is a part of the Toll-like 4 signaling complex with an indispensable role in activation of the lipopolysaccharide (LPS) signaling pathway and thus a suitable target for the therapeutic inhibition of TLR4 signaling. Elucidation of MD-2 structure provides a foundation for rational design of inhib...
| Main Authors: | , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
American Society for Biochemistry and Molecular Biology
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/29511 |