Characterization of Brucella abortus O-polysaccharide and core lipopolysaccharide mutants and demonstration that a complete core is required for rough vaccines to be efficient against Brucella abortus and Brucella ovis in the mouse model

Characterization of Brucella abortus O-polysaccharide and core lipopolysaccharide mutants and demonstration that a complete core is required for rough vaccines to be efficient against Brucella abortus and Brucella ovis in the mouse model

Brucella abortus rough lipopolysaccharide (LPS) mutants were obtained by transposon insertion into two wbk genes (wbkA [putative glycosyltransferase; formerly rfbU] and per [perosamine synthetase]), into manB (pmm [phosphomannomutase; formerly rfbK]), and into an unassigned gene. Consistent with gen...

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Bibliographic Details
Main Authors: Monreal, D. (Daniel), Grillo, M.J. (María Jesús), González-Fernández, D. (David), Marin, C.M. (C. M.), Miguel, M.J. (María Jesús) de, Lopez-Goñi, I. (Ignacio), Blasco, J.M. (J. M.), Cloeckaert, A. (Axel), Moriyon, I. (Ignacio)
Format: info:eu-repo/semantics/article
Language:eng
Published: American Society for Microbiology 2013
Subjects:
Brucella vaccine immunology
Brucella abortus immunology
Brucellosis prevention and control
Lipopolysaccharides chemistry
O antigens chemistry
Female
Online Access:https://hdl.handle.net/10171/29521

Internet

https://hdl.handle.net/10171/29521

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