New antagonist agents of Neuropeptide Y receptors

In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists mill be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as ant...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Aldana, I. (Ignacio), Rivero, I. (Isabel), Rivero, A. (Argimiro), Huenchuñir, P. (Patricio), Frigola, C. (Carmen), Alonso, M.L. (María Luisa), Monge, A. (Antonio)
التنسيق: info:eu-repo/semantics/article
اللغة:eng
منشور في: Sociedade Brasileira de Química 2013
الموضوعات:
الوصول للمادة أونلاين:https://hdl.handle.net/10171/29641
الوصف
الملخص:In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists mill be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as antagonists of rNPY.