New antagonist agents of Neuropeptide Y receptors

In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists mill be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as ant...

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Bibliografske podrobnosti
Main Authors: Aldana, I. (Ignacio), Rivero, I. (Isabel), Rivero, A. (Argimiro), Huenchuñir, P. (Patricio), Frigola, C. (Carmen), Alonso, M.L. (María Luisa), Monge, A. (Antonio)
Format: info:eu-repo/semantics/article
Jezik:eng
Izdano: Sociedade Brasileira de Química 2013
Teme:
Online dostop:https://hdl.handle.net/10171/29641
Opis
Izvleček:In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists mill be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as antagonists of rNPY.