Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine

Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine

Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation from smooth (S) to rough (R) bacteria, the latter being inefficacious as...

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Bibliographic Details
Main Authors: Mancilla, M. (Marcos), Grillo, M.J. (María Jesús), Miguel, M.J. (María Jesús) de, Lopez-Goñi, I. (Ignacio), San-Roman, B. (Beatriz), Zabalza-Barangua, A. (Ana), Moriyon, I. (Ignacio)
Format: info:eu-repo/semantics/article
Language:eng
Published: BioMed Central 2014
Subjects:
O-polysaccharide synthesis
Gram-negative bacteria
Smooth lipopolysaccharide
DNA polymorphism
Genomic island
PCR assay
Abortus
Virulence
Gene
Identification
Online Access:https://hdl.handle.net/10171/35589

Internet

https://hdl.handle.net/10171/35589

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