Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance...

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Bibliographic Details
Main Authors: Aldana, I. (Ignacio), Monge, A. (Antonio), Deharo, E. (Eric), Pérez-Silanes, S. (Silvia), Burguete, A. (Asunción), Galiano, S. (Silvia), Pabon, A. (Adriana), Gil, A. (Ana)
Format: info:eu-repo/semantics/article
Language:eng
Published: MDPI (Molecular Diversity Preservation International) 2014
Subjects:
Chalcone
Quinoxaline 1,4-di-N-oxide
Quinoxaline
Antimalarial agents
Plasmodium falciparum
Online Access:https://hdl.handle.net/10171/35725

Internet

https://hdl.handle.net/10171/35725

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