Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance...
| Main Authors: | , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
MDPI (Molecular Diversity Preservation International)
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/35725 |
| _version_ | 1793400192768147456 |
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| author | Aldana, I. (Ignacio) Monge, A. (Antonio) Deharo, E. (Eric) Pérez-Silanes, S. (Silvia) Burguete, A. (Asunción) Galiano, S. (Silvia) Pabon, A. (Adriana) Gil, A. (Ana) |
| author_facet | Aldana, I. (Ignacio) Monge, A. (Antonio) Deharo, E. (Eric) Pérez-Silanes, S. (Silvia) Burguete, A. (Asunción) Galiano, S. (Silvia) Pabon, A. (Adriana) Gil, A. (Ana) |
| author_sort | Aldana, I. (Ignacio) |
| collection | DSpace |
| description | We report the synthesis and antimalarial activities of eighteen quinoxaline and
quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds
1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-35725 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | MDPI (Molecular Diversity Preservation International) |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-357252020-03-03T23:50:33Z Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents Aldana, I. (Ignacio) Monge, A. (Antonio) Deharo, E. (Eric) Pérez-Silanes, S. (Silvia) Burguete, A. (Asunción) Galiano, S. (Silvia) Pabon, A. (Adriana) Gil, A. (Ana) Chalcone Quinoxaline 1,4-di-N-oxide Quinoxaline Antimalarial agents Plasmodium falciparum We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring. 2014-04-08T09:58:37Z 2014-04-08T09:58:37Z 2014-02-18 info:eu-repo/semantics/article https://hdl.handle.net/10171/35725 eng PIUNA Project of the University of Navarra info:eu-repo/semantics/openAccess application/pdf MDPI (Molecular Diversity Preservation International) |
| spellingShingle | Chalcone Quinoxaline 1,4-di-N-oxide Quinoxaline Antimalarial agents Plasmodium falciparum Aldana, I. (Ignacio) Monge, A. (Antonio) Deharo, E. (Eric) Pérez-Silanes, S. (Silvia) Burguete, A. (Asunción) Galiano, S. (Silvia) Pabon, A. (Adriana) Gil, A. (Ana) Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents |
| title | Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents |
| title_full | Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents |
| title_fullStr | Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents |
| title_full_unstemmed | Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents |
| title_short | Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents |
| title_sort | synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-plasmodium falciparum agents |
| topic | Chalcone Quinoxaline 1,4-di-N-oxide Quinoxaline Antimalarial agents Plasmodium falciparum |
| url | https://hdl.handle.net/10171/35725 |
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