Pharmacokinetic/Pharmacodynamic modelling during development of novel drugs for the treatment of sleep disorders
The goal of the present work was to describe the sleep effects of the hypnotic drug zolpidem in rats using a semi-mechanistic pharmacokinetic-pharmacodynamic (PK/PD) Markov-chain model. Data were obtained from healthy Sprague-Dawley rats in which EEG was continuously recorded for at least two days...
| Main Authors: | , , |
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Language: | eng |
| Published: |
Servicio de Publicaciones de la Universidad de Navarra
2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/38190 |