Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study
Background: Substantial evidence suggests that consuming 1–2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content i...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Bio Med Central
2017
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| Online Access: | https://hdl.handle.net/10171/43148 |
| _version_ | 1793400014361329664 |
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| author | Gomez-Gracia, E. (Enrique) Gutierrez-Bedmar, M. (Mario) Garcia-Rodriguez, A. (Antonio) Muñoz, M.A. (Miguel Angel) Sorli, J.V. (Jose V.) Bullo, M. (Monica) Serra-Majem, L. (Luis) Lapetra, J. (José) Fiol, M. (Miquel) Aros, F. (Fernando) Estruch, R. (Ramón) Fito, M. (Montserrat) Ros, E. (Emilio) Corella, D. (Dolores) Salas-Salvado, J. (Jordi) Ruiz-Canela, M. (Miguel) Wärnberg, J. (Julia) Stampfer, M. (Meir) Gea, A. (Alfredo) Downer, M.K. (Mary Kathryn) Martinez-Gonzalez, M.A. (Miguel Ángel) |
| author_facet | Gomez-Gracia, E. (Enrique) Gutierrez-Bedmar, M. (Mario) Garcia-Rodriguez, A. (Antonio) Muñoz, M.A. (Miguel Angel) Sorli, J.V. (Jose V.) Bullo, M. (Monica) Serra-Majem, L. (Luis) Lapetra, J. (José) Fiol, M. (Miquel) Aros, F. (Fernando) Estruch, R. (Ramón) Fito, M. (Montserrat) Ros, E. (Emilio) Corella, D. (Dolores) Salas-Salvado, J. (Jordi) Ruiz-Canela, M. (Miguel) Wärnberg, J. (Julia) Stampfer, M. (Meir) Gea, A. (Alfredo) Downer, M.K. (Mary Kathryn) Martinez-Gonzalez, M.A. (Miguel Ángel) |
| author_sort | Gomez-Gracia, E. (Enrique) |
| collection | DSpace |
| description | Background: Substantial evidence suggests that consuming 1–2 servings of fish per week, particularly oily fish
(e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid
content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk,
but this relationship remains unclear.
Methods: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at
baseline. In this study, we evaluated associations between mercury exposure, fish consumption and cardiovascular
disease. We randomly selected 147 of the 288 cases diagnosed with cardiovascular disease during follow-up and
matched them on age and sex to 267 controls. Instrumental neutron activation analysis was used to assess toenail
mercury concentration. In-person interviews, medical record reviews and validated questionnaires were used to
assess fish consumption and other covariates. Information was collected at baseline and updated yearly during
follow-up. We used conditional logistic regression to evaluate associations in the total nested case-control study,
and unconditional logistic regression for population subsets.
Results: Mean (±SD) toenail mercury concentrations (μg per gram) did not significantly differ between cases
(0.63 (±0.53)) and controls (0.67 (±0.49)). Mercury concentration was not associated with cardiovascular disease in
any analysis, and neither was fish consumption or n-3 fatty acids. The fully-adjusted relative risks for the highest
versus lowest quartile of mercury concentration were 0.71 (95% Confidence Interval [CI], 0.34, 1.14; ptrend = 0.37)
for the nested case-control study, 0.74 (95% CI, 0.32, 1.76; ptrend = 0.43) within the Mediterranean diet intervention
group, and 0.50 (95% CI, 0.13, 1.96; ptrend = 0.41) within the control arm of the trial. Associations remained null
when mercury was jointly assessed with fish consumption at baseline and during follow-up. Results were similar
in different sensitivity analyses.Conclusions: We found no evidence that mercury exposure from regular fish consumption increases cardiovascular
disease risk in a population of Spanish adults with high cardiovascular disease risk and high fish consumption. This
implies that the mercury content in fish does not detract from the already established cardiovascular benefits of fish
consumption. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-43148 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2017 |
| publisher | Bio Med Central |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-431482023-03-13T11:03:59Z Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study Gomez-Gracia, E. (Enrique) Gutierrez-Bedmar, M. (Mario) Garcia-Rodriguez, A. (Antonio) Muñoz, M.A. (Miguel Angel) Sorli, J.V. (Jose V.) Bullo, M. (Monica) Serra-Majem, L. (Luis) Lapetra, J. (José) Fiol, M. (Miquel) Aros, F. (Fernando) Estruch, R. (Ramón) Fito, M. (Montserrat) Ros, E. (Emilio) Corella, D. (Dolores) Salas-Salvado, J. (Jordi) Ruiz-Canela, M. (Miguel) Wärnberg, J. (Julia) Stampfer, M. (Meir) Gea, A. (Alfredo) Downer, M.K. (Mary Kathryn) Martinez-Gonzalez, M.A. (Miguel Ángel) Toenail biomarker PREDIMED Mediterranean diet Cardiovascular disease Fish Mercury Materias Investigacion::Ciencias de la Salud::Salud pública Background: Substantial evidence suggests that consuming 1–2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. Methods: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline. In this study, we evaluated associations between mercury exposure, fish consumption and cardiovascular disease. We randomly selected 147 of the 288 cases diagnosed with cardiovascular disease during follow-up and matched them on age and sex to 267 controls. Instrumental neutron activation analysis was used to assess toenail mercury concentration. In-person interviews, medical record reviews and validated questionnaires were used to assess fish consumption and other covariates. Information was collected at baseline and updated yearly during follow-up. We used conditional logistic regression to evaluate associations in the total nested case-control study, and unconditional logistic regression for population subsets. Results: Mean (±SD) toenail mercury concentrations (μg per gram) did not significantly differ between cases (0.63 (±0.53)) and controls (0.67 (±0.49)). Mercury concentration was not associated with cardiovascular disease in any analysis, and neither was fish consumption or n-3 fatty acids. The fully-adjusted relative risks for the highest versus lowest quartile of mercury concentration were 0.71 (95% Confidence Interval [CI], 0.34, 1.14; ptrend = 0.37) for the nested case-control study, 0.74 (95% CI, 0.32, 1.76; ptrend = 0.43) within the Mediterranean diet intervention group, and 0.50 (95% CI, 0.13, 1.96; ptrend = 0.41) within the control arm of the trial. Associations remained null when mercury was jointly assessed with fish consumption at baseline and during follow-up. Results were similar in different sensitivity analyses.Conclusions: We found no evidence that mercury exposure from regular fish consumption increases cardiovascular disease risk in a population of Spanish adults with high cardiovascular disease risk and high fish consumption. This implies that the mercury content in fish does not detract from the already established cardiovascular benefits of fish consumption. 2017-03-28T11:55:30Z 2017-03-28T11:55:30Z 2017 info:eu-repo/semantics/article https://hdl.handle.net/10171/43148 eng info:eu-repo/semantics/openAccess application/pdf Bio Med Central |
| spellingShingle | Toenail biomarker PREDIMED Mediterranean diet Cardiovascular disease Fish Mercury Materias Investigacion::Ciencias de la Salud::Salud pública Gomez-Gracia, E. (Enrique) Gutierrez-Bedmar, M. (Mario) Garcia-Rodriguez, A. (Antonio) Muñoz, M.A. (Miguel Angel) Sorli, J.V. (Jose V.) Bullo, M. (Monica) Serra-Majem, L. (Luis) Lapetra, J. (José) Fiol, M. (Miquel) Aros, F. (Fernando) Estruch, R. (Ramón) Fito, M. (Montserrat) Ros, E. (Emilio) Corella, D. (Dolores) Salas-Salvado, J. (Jordi) Ruiz-Canela, M. (Miguel) Wärnberg, J. (Julia) Stampfer, M. (Meir) Gea, A. (Alfredo) Downer, M.K. (Mary Kathryn) Martinez-Gonzalez, M.A. (Miguel Ángel) Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study |
| title | Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study |
| title_full | Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study |
| title_fullStr | Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study |
| title_full_unstemmed | Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study |
| title_short | Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study |
| title_sort | mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the predimed (prevention with mediterranean diet) study |
| topic | Toenail biomarker PREDIMED Mediterranean diet Cardiovascular disease Fish Mercury Materias Investigacion::Ciencias de la Salud::Salud pública |
| url | https://hdl.handle.net/10171/43148 |
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