rAAV8-mediated in vivo reprogramming of striatal astrocytes into neurons as a potential therapeutic strategy for neurodegenerative diseases

rAAV8-mediated in vivo reprogramming of striatal astrocytes into neurons as a potential therapeutic strategy for neurodegenerative diseases

CNS neurodegenerative disorders represent a major health problem worldwide. In PD, the progressive loss of miDA neurons leads to an irreversible dopamine deficiency in the striatum, ultimately triggering the appearance of the cardinal motor symptoms that typically characterize this movement disorder...

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Bibliographic Details
Main Authors: Pignataro, D. (Diego), González-Aseguinolaza, G. (Gloria), Lanciego, J.L. (José Luis)
Format: info:eu-repo/semantics/doctoralThesis
Language:eng
Published: 2018
Subjects:
neurodegenerative diseases
Parkinson
gene therapy
Materias Investigacion::Ciencias de la Salud::Enfermedades y ataques cerbrovasculares
Online Access:https://hdl.handle.net/10171/50966

Internet

https://hdl.handle.net/10171/50966

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