rAAV8-mediated in vivo reprogramming of striatal astrocytes into neurons as a potential therapeutic strategy for neurodegenerative diseases
CNS neurodegenerative disorders represent a major health problem worldwide. In PD, the progressive loss of miDA neurons leads to an irreversible dopamine deficiency in the striatum, ultimately triggering the appearance of the cardinal motor symptoms that typically characterize this movement disorder...
| Auteurs principaux: | , , |
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Langue: | eng |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://hdl.handle.net/10171/50966 |