Evaluation of skin permeation and retention of topical dapsone in murine cutaneous leishmaniasis lesions

Evaluation of skin permeation and retention of topical dapsone in murine cutaneous leishmaniasis lesions

The oral administration of dapsone (DAP) for the treatment of cutaneous leishmaniasis (CL) is effective, although serious hematological side effects limit its use. In this study, we evaluated this drug for the topical treatment of CL. As efficacy depends on potency and skin penetration, we first det...

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Main Authors: Espuelas, S. (Socorro), Irache, J.M. (Juan Manuel), Sanmartin-Grijalba, C. (Carmen), Gonzalez-Peñas, E. (Elena), Navarro-Blasco, I. (Iñigo), Schwartz, J. (Juana), Calvo-Bacaicoa, A. (Alba), Moreno-Amatria, E. (Esther)
Format: info:eu-repo/semantics/article
Language:English
Published: 2019
Subjects:
Dapsone
Topical treatment
Cutaneous leishmaniasis
Pluronic lecithin emulgel
Iron
Online Access:https://hdl.handle.net/10171/58480

Internet

https://hdl.handle.net/10171/58480

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