Oral efficacy of a diselenide compound loaded in nanostructured lipid carriers in a murine model of visceral leishmaniasis

Oral efficacy of a diselenide compound loaded in nanostructured lipid carriers in a murine model of visceral leishmaniasis

Leishmaniasis urgently needs new oral treatments, as it is one of the most important neglected tropical diseases that affects people with poor resources. The drug discovery pipeline for oral administration currently discards entities with poor aqueous solubility and permeability (class IV compounds...

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Main Authors: Etxebeste-Mitxeltorena, M. (Mikel), Moreno-Amatria, E. (Esther), Carvalheiro, M. (Manuela), Calvo-Bacaicoa, A. (Alba), Navarro-Blasco, I. (Iñigo), Gonzalez-Peñas, E. (Elena), Alvarez-Galindo, J.I. (José Ignacio), Plano-Amatriain, D. (Daniel), Irache, J.M. (Juan Manuel), Almeida, A.J. (Antonio J.), Sanmartin-Grijalba, C. (Carmen), Espuelas, S. (Socorro)
Format: info:eu-repo/semantics/article
Language:English
Published: 2022
Subjects:
Diselenide
Nanostructured lipid carriers
Visceral leishmanisis
L. infantum
Oral treatment
Online Access:https://hdl.handle.net/10171/62944

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https://hdl.handle.net/10171/62944

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