FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their coexpression may predict FGFR-targeted therapy efficacy

FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their coexpression may predict FGFR-targeted therapy efficacy

Background: Fibroblast growth factor receptor (FGFR)1 and FGFR4 have been associated with tumorigenesis in a variety of tumour types. As a therapeutic approach, their inhibition has been attempted in different types of malignancies, including lung cancer, and was initially focused on FGFR1-amplifi...

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Main Authors: Quintanal-Villalonga, Á. (Álvaro), Ferrer, I. (Irene), Guruceaga, E. (Elizabeth), Cirauqui, C. (Cristina), Marrugal, Á. (Ángela), Ojeda, L. (Laura), García, S. (Santiago), Zugazagoitia, J. (Jon), Muñoz-Galván, S. (Sandra), López-Ríos, F. (Fernando), Montuenga-Badia, L.M. (Luis M.), Vicent, S. (Silvestre), Molina-Pinelo, S. (Sonia), Carnero, A. (Amancio), Paz-Ares, L. (Luis)
Format: info:eu-repo/semantics/article
Language:eng
Published: 2023
Subjects:
FGFR1
FGFR4
N-cadherin
Predictive biomarker
FGFR inhibitors
Online Access:https://hdl.handle.net/10171/66276

Internet

https://hdl.handle.net/10171/66276

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