Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes

Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes

Antimicrobial peptides (AMPs) contribute to an effective protection against infections. The antibacterial function of AMPs depends on their interactions with microbial membranes and lipids, such as lipopolysaccharide (LPS; endotoxin). Hyperinflammation induced by endotoxin is a key factor in bacteri...

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Main Authors: Schromm, A.B. (Andra B.), Paulowski, L. (Laura), Kaconis, Y. (Yani), Kopp, F. (Franziska), Koistinen, M. (Max), Donoghue, A. (Annemarie), Keese, S. (Susanne), Nehls, C. (Christian), Wernecke, J. (Julia), Garidel, P. (Patrick), Sevcsik, E. (Eva), Lohner, K. (Karl), Sánchez-Gómez, S. (Susana), Martinez-de-Tejada, G. (Guillermo), Brandenburg, K. (Klaus), Brameshuber, M. (Mario), Schütz, G.J. (Gerhard J.), Andrä, J. (Jörg), Gutsmann, T. (Thomas)
Format: info:eu-repo/semantics/article
Language:eng
Published: PNAS 2024
Subjects:
Antimicrobial peptides
Endotoxin
Hyperinflammation
Immune regulation
Membrane domains
Online Access:https://hdl.handle.net/10171/68498

Internet

https://hdl.handle.net/10171/68498

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