Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes

Antimicrobial peptides (AMPs) contribute to an effective protection against infections. The antibacterial function of AMPs depends on their interactions with microbial membranes and lipids, such as lipopolysaccharide (LPS; endotoxin). Hyperinflammation induced by endotoxin is a key factor in bacteri...

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Main Authors: Schromm, A.B. (Andra B.), Paulowski, L. (Laura), Kaconis, Y. (Yani), Kopp, F. (Franziska), Koistinen, M. (Max), Donoghue, A. (Annemarie), Keese, S. (Susanne), Nehls, C. (Christian), Wernecke, J. (Julia), Garidel, P. (Patrick), Sevcsik, E. (Eva), Lohner, K. (Karl), Sánchez-Gómez, S. (Susana), Martinez-de-Tejada, G. (Guillermo), Brandenburg, K. (Klaus), Brameshuber, M. (Mario), Schütz, G.J. (Gerhard J.), Andrä, J. (Jörg), Gutsmann, T. (Thomas)
格式: info:eu-repo/semantics/article
语言:eng
出版: PNAS 2024
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在线阅读:https://hdl.handle.net/10171/68498