The antimicrobial peptide cathelicidin and polymyxin B neutralize endotoxins by a multifactorial mechanism including not only direct LPS-interaction but also targeting of host cell membrane domains

The antimicrobial peptide cathelicidin and polymyxin B neutralize endotoxins by a multifactorial mechanism including not only direct LPS-interaction but also targeting of host cell membrane domains

Antimicrobial peptides (AMPs) contribute to an effective protection against infections. The antibacterial function of AMPs depends on their interactions with microbial membranes and lipids, such as lipopolysaccharide (LPS; endotoxin). Hyperinflammation induced by endotoxin is a key factor in bacteri...

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Bibliographic Details
Main Authors: Schromm, A.B. (Andra B.), Paulowski, L. (Laura), Kaconis, Y. (Yani), Kopp, F. (Franziska), Koistinen, M. (Max), Donoghue, A. (Annemarie), Keese, S. (Susanne), Nehls, C. (Christian), Wernecke, J. (Julia), Garidel, P. (Patrick), Sevcsik, E. (Eva), Lohner, K. (Karl), Sánchez-Gómez, S. (Susana), Martinez-de-Tejada, G. (Guillermo), Brandenburg, K. (Klaus), Brameshuber, M. (Mario), Schütz, G.J. (Gerhard J.), Andrä, J. (Jörg), Gutsmann, T. (Thomas)
Format: info:eu-repo/semantics/article
Language:eng
Published: PNAS 2024
Subjects:
Antimicrobial peptides
Endotoxin
Hyperinflammation
Immune regulation
Membrane domains
Online Access:https://hdl.handle.net/10171/68565

Internet

https://hdl.handle.net/10171/68565

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