Permeability enhancers sensitize β-lactamase-expressing Enterobacteriaceae and Pseudomonas aeruginosa to β-lactamase inhibitors, thereby restoring their β-lactam susceptibility

Permeability enhancers sensitize β-lactamase-expressing Enterobacteriaceae and Pseudomonas aeruginosa to β-lactamase inhibitors, thereby restoring their β-lactam susceptibility

Objectives: β-lactamases are the major resistance determinant for β-lactam antibiotics in Gram-negative bacteria. Although there are β-lactamase inhibitors (BLIs) available, β-lactam-BLI combinations are increasingly being neutralised by diverse mechanisms of bacterial resistance. This study hypothe...

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Bibliographic Details
Main Authors: Ferrer-Espada, R. (Raquel), Sánchez-Gómez, S. (Susana), Pitts, B. (Betsey), Stewart, P.S. (Philip S.), Martinez-de-Tejada, G. (Guillermo)
Format: info:eu-repo/semantics/article
Language:eng
Published: Elsevier 2024
Subjects:
Biofilm
Escherichia coli
Klebsiella pneumoniae
Pseudomonas aeruginosa
Synergy
β-lactamase inhibitor
Online Access:https://hdl.handle.net/10171/68570

Internet

https://hdl.handle.net/10171/68570

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