Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds

Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds

A set of thirteen cassane-type diterpenes was synthesized and an expedient synthetic route was used to evaluate 14-desmethyl analogs of the most active tested cassane. The anti-inflammatory activities of these 13 compounds were evaluated on a lipopolysaccharide (LPS)-activated RAW 264.7 cell line by...

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Bibliographic Details
Main Authors: Zentar, Houda, Jannus, Fatin, Medina-O’Donnell, Marta, Lupiáñez, José A., Justicia, José, Alvarez-Manzaneda Roldán, Ramón Jesús, Reyes-Zurita, Fernando J., Alvarez-Manzaneda, Enrique, Chahboun, Rachid
Format: info:eu-repo/semantics/article
Language:English
Published: MDPI 2022
Subjects:
natural products
semisynthesis
cassane diterpenoids
anti-inflammatory activity
anti-cancer activity
Online Access:http://hdl.handle.net/10835/13934

Internet

http://hdl.handle.net/10835/13934

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